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Home > Prescription Drugs > Antibiotics > Oxacillin: Penicillinase Resistant
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Oxacillin: Penicillinase-Resistant
Oxacillin is a semisynthetic antibiotic which belongs to the group of penicillinase-resistant penicillins. Oxacillin is commercially used as monohydrate, but its power is expressed as base oxacillin. It is a white crystalline powder, slightly soluble in water.
Oxicillin is bactericide, it adheres to the bacterial penicillin-binding proteins and that way, it inhibits the bacteria’s cell wall synthesis. Oxicillin resists the effects of penicillinases, which are enzymes that inactivate the penicillin, thus increasing resistance to the antibiotic, and therefore it is active against many kinds of penicillinase-producing bacteria. However, some kinds of bacteria can remain resistant. In addition, oxicillin is active against some aerobic or anaerobic gram positive bacillus, but has no significant effect on negative bacillus.
This antibiotic is effective in infections caused by penicillinase-producing staphylococcus, pneumococcus, and streptococcus, such as skin infections and infections in the subcutaneous cell tissue, upper respiratory tract infections, lower respiratory tract infections, urogenital tract infections, septicemia, acute and subacute endocarditis, osteomyelitis, and septic arthritis. The drug should not be used orally for the treatment of severe infections caused by these microorganisms.
Possible side effects of oxacilling include dark yellow or brown urine, fever, chills, difficulty breathing, wheezing, sore throat, headaches, red spots on the skin, redness, less frequent passing of urine, blistering, peeling or loosening of the skin, seizures, severe or watery diarrhea, unusual weakness or tiredness, unusual bleeding or bruising, and yellowing of the eyes or skin. Other mild side effects which do not generally require medical attention include nausea, vomiting, diarrhea, and sore mouth.
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